涓枃鎽樿 杞寲鐢熼暱鍥犲瓙尾錛坱ransforming growth factor-尾錛孴GF-尾錛夋槸涓�縐嶅鏁堟�х粏鑳?yōu)鍥犲瓙锛屽睘浜庤皟鑺偩l嗚優(yōu)鐢熼暱鍜屽垎鍖栫殑TGF-尾瓚呭鏃忋�傚湪鑲跨槫鍙戝睍鐨勫悗鏈燂紝鑷垎娉屽拰鏃佸垎娉岀殑TGF-尾鍙兘閫氳繃璇卞涓婄毊-闂磋川杞寲銆佷績榪涜偪鐦よ綆＄敓鎴愩�佽皟鑺傚厤鐤姂鍒舵潵璋冩帶鑲跨槫鐨勮漿縐誨拰澶嶅彂銆傚洜姝わ紝TGF-尾琚涓烘槸鏅氭湡鑲跨槫鐢熼暱銆佽繘灞曞拰杞Щ娼滆兘鐨勯噸瑕佸洜绱犮�備腑鍜屾垨闃繪柇TGF-尾鏄竴縐嶅共棰勫拰騫叉壈鑲跨槫鐢熼暱鍏抽敭鍚姩瀛愮殑鐙壒鏂規(guī)硶錛屽彲鑳戒細鎻愪緵涓�涓柊鐨勬不鐤楁満浼氥�傛鏂囧氨TGF-尾鐨勭粨鏋勩�佸姛鑳藉強鍏跺湪鑲跨槫寰幆澧冧腑鐨勪綔鐢ㄦ満鍒惰繘琛岀患榪幫紝騫跺垪涓句簡涓�浜涘湪鐮旂殑闈跺悜TGF-尾鑽墿錛屾棬鍦ㄤ負鎶楄偪鐦よ嵂鐗╃殑寮�鍙戝拰涓村簥搴旂敤鎻愪緵鍙傝�冦�?/p>
姝ｆ枃 鑲跨槫寰幆澧冩槸鑲跨槫緇嗚優(yōu)鍦ㄦ満浣撳唴璧栦互鐢熷瓨鐨勫眬閮ㄧ粍緇囩幆澧?sup style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 12px;">[1]錛屽寘鎷偪鐦ょ粏鑳?yōu)鍛ㄥ洿鐨勫悇绉嵕l嗚優(yōu)錛堝唴鐨粏鑳?yōu)銆佸厤鐤粏鑳?yōu)銆佹垚綰ょ淮緇嗚優(yōu)絳夛級鍜屽悇縐嶇粏鑳?yōu)澶柧l勫垎錛堢粏鑳?yōu)澶栧燌櫞ㄣ�佺粏鑳?yōu)鍥犲瓙銆佹縺绱犵瓑錛夈�傚畠浠洿緇曞湪鑲跨槫緇嗚優(yōu)鍛ㄥ洿錛岀敱琛�綆＄綉婊嬪吇錛屽茍鐩鎬簰浣滅敤錛屽叡鍚岄樆紕嶆満浣撳鑲跨槫緇嗚優(yōu)鐨勫厤鐤潃浼や綔鐢紝浠庤�屼績榪涜偪鐦ょ殑澧炴畺銆佹伓鍖栧拰杞Щ[2]銆備綔涓轟竴縐嶅鍔熻兘緇嗚優(yōu)鍥犲瓙錛岃偪鐦ゅ井鐜涓殑杞寲鐢熼暱鍥犲瓙尾錛坱ransforming growth factor-尾錛孴GF-尾錛夊湪浼楀鎭舵�ц偪鐦ょ殑鍙戠敓銆佸彂灞曞拰杞Щ涓兘鍙戞尌浜嗚嚦鍏抽噸瑕佺殑浣滅敤錛岃秺鏉ヨ秺澶氱殑璇佹嵁琛ㄦ槑鍏跺叿鏈夋垚涓鴻偪鐦ゅ厤鐤不鐤楅澏鐐圭殑娼滃姏銆傛湰鏂囧TGF-尾鐨勭粨鏋勩�佸姛鑳藉強鍏墮澏鍚戣嵂鐗╃爺絀惰繘灞曠瓑榪涜緇艱堪錛屼負闈跺悜TGF-尾鎶楄偪鐦よ嵂鐗╃殑鐮斿彂鎻愪緵鍙傝�冦�?/p> 1 TGF-尾鍙婁俊鍙烽�氳礬姒傝堪 TGF-尾瀹舵棌搴炲ぇ錛岃嚜1978騫撮嬈″垎紱昏幏寰楄瀹舵棌絎竴涓垚鍛楾GF-尾浠ユ潵錛岃縿浠婂凡鏈塗GF-尾鐨?縐嶄簹鍨嬨�佹姂鍒剁礌/嬋�媧葷礌銆侀褰㈡�佸彂鐢熻泲鐧藉拰鎶楃﹩鍕掔嬋�绱犵瓑瀹舵棌鎴愬憳琚浉緇у彂鐜?sup style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 12px;">[3]銆傚叾涓紝TGF-尾鏄瀹舵棌涓爺絀惰緝澶氱殑涓�縐嶅鍔熻兘緇嗚優(yōu)鍥犲瓙銆俆GF-尾鏄浉瀵瑰垎瀛愯川閲忎負25 000鐨勫悓婧愪簩鑱氫綋錛岀敱2涓浉瀵瑰垎瀛愯川閲忎負12 500鐨勪簹鍩洪�氳繃浜岀～閿繛鎺ヨ�屾垚[4]銆俆GF-尾涓嶅悓浜氬瀷鍦ㄧ墿縐嶉棿鐨勫垎甯冪暐鏈変笉鍚岋紝TGF-尾1銆乀GF-尾2銆乀GF-尾3鍦ㄥ摵涔沖姩鐗╀腑楂樺害淇濆畧錛岀紪鐮佸熀鍥犲叿鏈?0%~80%鍚屾簮鎬э紝琚涓哄嚭鐜板湪鍚庣敓鍔ㄧ墿榪涘寲鐨勬棭鏈?sup style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 12px;">[5]錛汿GF-尾4鍜孴GF-尾5鐩墠鐮旂┒杈冨皯錛屼富瑕佸瓨鍦ㄤ簬楦熺被鍜屼袱鏍栫被鍔ㄧ墿浣撳唴銆傜敱浜庡寘鎷ぇ澶氭暟鍏嶇柅緇嗚優(yōu)鍦ㄥ唴鐨勫嚑涔庢墍鏈夌粏鑳?yōu)鍧囧垎娉屾綔浼忓舰寮廡GF-尾1[6-7]錛屼笖TGF-尾1鏄偪鐦ょ粏鑳?yōu)涓〃杈炬渶楂樼殑浜氬瀷[7]錛屾晠鑰孴GF-尾1鏄爺絀禩GF-尾鐨勭劍鐐廣�俆GF-尾閫氳繃鑷垎娉屾垨鏃佸垎娉岀殑鏂瑰紡浠ュ墠浣撹泲鐧借川鐨勫艦寮忚〃杈?sup style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 12px;">[8]錛屽湪鑲跨槫寰幆澧冧腑緇忚繃鍓垏鍏禢绔歡榪熺浉鍏寵偨鍚庡艦鎴愭垚鐔熻偨錛?涓猅GF-尾鎴愮啛鑲藉垎瀛愬啀閫氳繃褰㈡垚閾鵑棿浜岀～閿渶緇堝緱鍒板叿鏈夌敓鐗╂椿鎬х殑鍚屾簮浜岃仛浣?sup style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 12px;">[6]銆傛垚鐔熺殑TGF-尾浠庡叾娼滀紡褰㈠紡涓縺媧誨拰閲婃斁錛屽茍涓庤川鑶滀笂鐨勫彈浣撶洿鎺ョ粨鍚堝惎鍔ㄤ俊鍙瘋漿瀵肩殑綰ц仈鍙嶅簲錛屼粠鑰屽紩鍙戝鍝嶅簲緇嗚優(yōu)鐨勭敓鐗╀綔鐢ㄣ�?/p> 鐮旂┒琛ㄦ槑錛屽彂鑲蹭腑鐨勮儦鑳庡拰鎴愬勾鍔ㄧ墿涓墍鏈夌被鍨嬬粏鑳?yōu)閮芥惡甯GF-尾鍙椾綋錛圱GF-尾 receptor錛孴GF-尾R)錛屽叡鏈?縐嶄簹鍨?sup style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 12px;">[9]錛屽嵆TGF-尾R鈪犫�擳GF-尾R鈪ゃ�傝繖浜涘彈浣撳彲浠ラ�氳繃鍐呭湪鍌寲媧繪�у彂鍑轟俊鍙鳳紝涔熷彲浠ヤ綔涓轟績榪涙垨鎶戝埗閰嶄綋鍛堥�掔粰淇″彿鍙椾綋鐨勬劅鍙楀櫒TGF-尾R鏉ュ彂鎸ヤ綔鐢紝鍏朵腑琛ㄧ幇鍑哄唴鍦ㄥ偓鍖栨椿鎬х殑TGF-尾R鈪犲拰TGF-尾R鈪℃槸ATP渚濊禆鎬ц泲鐧芥縺閰訛紝N绔槸浜叉按鎬ц優(yōu)澶栧尯錛岃兘璇嗗埆閰嶄綋鐨勭壒瀹氱粨鏋勫煙錛屽叾嬈℃槸a铻烘棆璺ㄨ啘緇撴瀯鍩燂紝C绔槸鍏鋒湁嬋�閰舵椿鎬х殑鑳?yōu)鍐呭尯锛屾帴鍙桝TP騫剁７閰稿寲涓嬫父搴曠墿鐨勪笣姘ㄩ吀/鑻忔皚閰鎬綅鐐?sup style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 12px;">[10]錛涘彂鎸ヨ皟鑺備綔鐢ㄧ殑鎰熷彈鍣═GF-尾R鈪㈡槸闀跺祵鍦ㄧ粏鑳?yōu)鑶滀笂鐨劸p栬泲鐧斤紝涓嶇洿鎺ヤ笌TGF-尾緇撳悎錛屼絾鑳戒績榪汿GF-尾涓嶵GF-尾R鈪犮�乀GF-尾R鈪＄殑緇撳悎[11]銆?/p> TGF-尾涓庡彈浣撶殑緇撳悎鍚姩涓嬫父淇″彿閫氳礬錛屽寘鎷琒mad閫氳礬涓庨潪Smad閫氳礬銆係mad铔嬬櫧絀挎浜庣粏鑳?yōu)璐ㄤ笌缁嗚優(yōu)鏍镐箣闂村Q屾槸TGF-尾淇″彿杞榪涙牳鐨勪粙璐ㄨ泲鐧姐�傚湪Smad閫氳礬涓紝TGF-尾棣栧厛涓嶵GF-尾R鈪¤優(yōu)澶栨緇撳悎錛屽叾鑳?yōu)鍐厡D電粨鍚堝茍紓烽吀鍖朤GF-尾R鈪犵殑鑳?yōu)鍐呭?sup style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 12px;">[12]錛屾帴鐫�TGF-尾R鈪犻�氳繃鍦ㄥ叾C绔尯鍩熺殑鐗瑰畾涓濇皚閰告畫鍩哄鐨勭７閰稿寲嬋�媧籗mad2铔嬬櫧鍜孲mad3铔嬬櫧錛屽啀鎷涘嫙Smad4铔嬬櫧褰㈡垚Smad2/Smad3/Smad4寮傛簮涓夎仛浣撳鍚堢墿,璇ヤ笁鑱氫綋澶嶅悎鐗╅�氳繃鏍稿瓟榪涗漢緇嗚優(yōu)鏍革紝緇х畫涓庡悇縐嶈緟鍥犲瓙鐩鎬簰浣滅敤浠ヨ皟鎺GF-尾渚濊禆鐨勫熀鍥犺〃杈?sup style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 12px;">[10]錛岃鍥?銆傞櫎浜哠mad浠嬪鐨勭粡鍏鎬俊鍙烽�氳礬錛孴GF-尾涔熷彲浠ラ�氳繃鍏朵粬淇″彿閫氳礬璋冩帶鏈轟綋鐢熺悊榪囩▼錛屽寘鎷笣瑁傚師媧誨寲铔嬬櫧嬋�閰墮�氳礬銆丳I3K/Akt閫氳礬浠ュ強JAK/STAT絳変俊鍙烽�氳礬[13]銆備笣瑁傚師媧誨寲铔嬬櫧嬋�閰跺箍娉涘瓨鍦ㄤ簬鐪熸牳緇嗚優(yōu)鍐咃紝鑳介�氳繃TGF-尾淇″彿閫氳礬寮曡搗緇嗚優(yōu)鍙戠敓涓婄毊-闂磋川杞寲錛坋pithelial-mesenchymal transition錛孍MT錛?sup style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 12px;">[14]銆侾I3K/Akt閫氳礬鍒欐槸TGF-尾R涓庣７鑴傞叞鑲岄唶3嬋�閰剁殑p85浜氬熀緇撳悎鍚庯紝紓烽吀鍖栧茍嬋�媧諱笅娓稿簳鐗〢kt璋冩帶鍩哄洜琛ㄨ揪錛岃繘鑰屼績榪涜偪鐦ょ粏鑳?yōu)鐨勫娈栧拰铦{縐匯�傛澶栵紝嬋�媧葷殑Akt鍙槻姝mad3鐨勭７閰稿寲錛屼粠鑰岃“鍑廠mad3渚濊禆鎬т俊鍙蜂紶瀵箋�侸AK/STAT淇″彿閫氳礬涓俊鍙瘋漿瀵煎拰杞綍嬋�媧誨洜瀛?錛坰ignal transduction and activator of transcription 3錛孲TAT3錛夎JAK嬋�閰訛紙涓嶵GF-尾R鈪犵浉浜掍綔鐢級紓烽吀鍖栧茍嬋�媧伙紝浠ュ搷搴擳GF-尾騫惰皟鑺俆GF-尾闈跺熀鍥犱簹緹ょ殑琛ㄨ揪銆傚湪鎴愮氦緇寸粏鑳?yōu)涓Q孞AK/STAT閫氳礬鍏呭綋TGF-尾淇冪氦緇村寲浣滅敤鐨勪粙璐?sup style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 12px;">[15]銆俆GF-尾閫氳繃涓婅堪淇″彿杞緗戠粶錛屽緇嗚優(yōu)澧炴畺銆佸垎鍖栥�佸噵浜′互鍙婅綆＄敓鎴愮瓑鏂歸潰浜х敓閲嶈褰卞搷銆傚洜姝わ紝榪涗竴姝ユ槑紜甌GF-尾瀵硅偪鐦ょ粏鑳?yōu)鍙戞尌鐨勭敓鐗╁鍔熻兘鍙兘鍦ㄤ复搴婁笂湄撹偪鐦ら澏鍚戞踩潠楁彁渚涘弬鑰冦�?/p> 2 TGF-尾涓庤偪鐦?/strong> 鑲跨槫寰幆澧冧腑鐨凾GF-尾閫氳繃浣滅敤浜庤偪鐦ょ粏鑳?yōu)鍙婃溵Z綋鍏嶇柅緇嗚優(yōu)鏉ュ獎鍝嶈偪鐦ょ殑鍙戠敓銆佸彂灞曞拰杞Щ銆傞殢鐫�鑲跨槫鍙戝睍榪涚▼錛孴GF-尾琛ㄧ幇鍑哄弻閲嶄綔鐢紝鍗沖湪鑲跨槫緇嗚優(yōu)鐨勬伓鍙樺墠鏈燂紝TGF-尾閫氳繃鎶戝埗鑲跨槫緇嗚優(yōu)澧炴畺鍜屼績榪涜偪鐦ょ粏鑳?yōu)鍑嬩骸杩欎袱绉嶉�斿緞鏉ラ樆姝㈣偪鐦ゅ艦鎴愶紝鑰屼竴鏃﹁偪鐦ゅ湪鏈轟綋涓艦鎴愶紝TGF-尾鍒欓�氳繃璇卞EMT銆佷績榪涜偪鐦ゆ柊琛�綆＄敓鎴愩�佸府鍔╄偪鐦ょ粏鑳?yōu)鍙戠敓鍏嶇柅閫冮�哥瓑閫斿緞鏉ュ疄鐜拌偪鐦ょ殑緇х畫鍙戝睍涓庤漿縐匯�俆GF-尾鍦ㄨ偪鐦ゅ彂鐢熴�佸彂灞曡繘紼嬩腑鎵紨鍙屽垉鍓戠殑瑙掕壊錛岃繖縐嶅姛鑳界殑鐩告?zhèn)栨�ц縐頒負鈥淭GF-尾鎮(zhèn)栬鈥?sup style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 12px;">[16]銆?/p> 2.1 TGF-尾瀵硅偪鐦ょ殑鎶戝埗浣滅敤 鍦ㄨ偪鐦ゅ艦鎴愪箣鍓嶏紝TGF-尾鍙互閫氳繃鎶戝埗鑲跨槫緇嗚優(yōu)澧炴畺鍜屼績榪涜偪鐦ょ粏鑳?yōu)鍑嬩?縐嶉�斿緞鏉ュ彂鎸ユ姉鑲跨槫浣滅敤銆傚叾涓紝鎶戝埗鑲跨槫緇嗚優(yōu)澧炴畺鍙堟湁2縐嶉�斿緞錛氾紙1錛塗GF-尾璇卞緇嗚優(yōu)鍛ㄦ湡鎬т緷璧栨�ф縺閰舵姂鍒跺洜瀛恜15銆乸21鍜宲27鐨勮〃杈撅紝闃繪鑲跨槫緇嗚優(yōu)鍦ㄥ垎瑁傚懆鏈熶腑鐢盙1鏈熷悜S鏈熻繃娓★紱錛?錛塩-Myc鏄弬涓庣粏鑳?yōu)鐢熼暱鍜屽垎瑁傜殑涓昏铦{褰曞洜瀛愶紝TGF-尾閫氳繃涓嬭皟c-Myc鐨勮〃杈撅紝鎶戝埗鑲跨槫緇嗚優(yōu)鍒嗚[17]銆?/p> TGF-尾涓嶄粎鍙互鎶戝埗鑲跨槫緇嗚優(yōu)澧炴畺錛屼篃鍙互閫氳繃浣滅敤浜庡噵浜＄浉鍏蟲晥搴斿垎瀛愭潵淇冭繘鑲跨槫緇嗚優(yōu)鍑嬩骸銆侶umbert絳?sup style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 12px;">[18]鐨勫疄楠岃〃鏄庡湪浜洪粦鑹茬礌鐦や腑錛孴GF-尾鑳介�氳繃TGF-尾/Smad淇″彿閫氳礬璇卞鐧借鐥呮姂鍒跺洜瀛愶紙leukemia inhibitory factor錛孡IF錛夊垎娉屽鍔狅紝鑰孡IF閫氳繃紓烽吀鍖朣TAT3浣垮叾緇撳悎鍒?em style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">p21鍚姩瀛愪笂浠庤�岃瀵?em style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">p21鍩哄洜琛ㄨ揪錛屽悗鑰呬互鑳卞ぉ铔嬬櫧閰?/7渚濊禆鏂瑰紡璇卞鑲跨槫緇嗚優(yōu)鍑嬩骸銆傛澶栵紝鍦ㄥ師鍙戞�ц倽鐧屼腑TGF-尾鑳戒笂璋冩浜＄浉鍏寵泲鐧芥縺閰剁殑琛ㄨ揪錛岃瀵艱倽緇嗚優(yōu)鍙戠敓緇嗚優(yōu)鍑嬩骸[19] 錛屾彁紺哄寮篢GF-尾璇卞鐨勮偪鐦ょ粏鑳?yōu)鍑嬩骸锛屽彲鑳戒綔湄撹偪鐦ゅ湪鏃╂湡闃秾D電殑娌葷枟絳栫暐銆?/p> 2.2 TGF-尾瀵硅偪鐦ょ粏鑳?yōu)鐨勪績杩涗綔鐢?/span> 2.2.1 TGF-尾淇冭繘鑲跨槫鍙戠敓EMT 鑲跨槫褰㈡垚鍚庯紝鑲跨槫緇嗚優(yōu)閫氳繃EMT浠嬪鑲跨槫鐨勬蹈娑﹁漿縐昏繘紼嬨�傚湪姝よ繃紼嬩腑錛岀珛鏂瑰艦鐨勪笂鐨粏鑳?yōu)铦{鍙樹負鐙暱鐨勭漢閿や綋褰㈢殑闂磋川緇嗚優(yōu)錛屽け鍘葷粏鑳?yōu)鏋佹�э紝涓婄毊緇嗚優(yōu)鏍囧織鐗〦-閽欓粡铔嬬櫧鍑忓皯錛岄棿璐ㄧ粏鑳?yōu)鏍囧織鐗╂尝迮炶泲鐧借〃杈惧鍔犲Q岀粏鑳?yōu)涓庡熀搴曡啘鐨剺q炴帴涓уけ錛岀粏鑳?yōu)娴佸姩鎬у鍔狅紝鑲跨槫緇嗚優(yōu)鑾峰緱鍚戝懆鍥寸粍緇囪縼縐匯�佷鏡琚殑鑳藉姏[20]銆侲MT榪囩▼琚櫘閬嶈涓烘槸鑲跨槫杞Щ鐨勬牴鏈師鍥狅紝鑰孴GF-尾鏄嚑涔庢墍鏈変笂鐨粍緇囦腑鍙戠敓EMT蹇呬笉鍙皯鐨勮瀵煎洜瀛?sup style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 12px;">[11]銆傜帇鏍嬬瓑[21]閫氳繃瀵歸綆＄檶緇嗚優(yōu)杞煋TGF-尾1灝忓共鎵癛NA闄嶄綆TGF-尾1琛ㄨ揪錛岄殢鍚庡彂鐜拌緇嗚優(yōu)鐨凟-閽欓粡铔嬬櫧琛ㄨ揪涓婅皟錛屾嘗褰㈣泲鐧借〃杈句笅璋冿紝涓旇偪鐦ょ粏鑳?yōu)鐨勪镜琚兘鍔涢檷浣庡Q岃鏄嶵GF-尾1鏄績榪涢綆＄檶緇嗚優(yōu)鍙戠敓EMT榪囩▼鐨勬湁鏁堝洜瀛愩�傛澶栵紝鍦ㄨ偪鐦よ漿縐誨悗鐨勫畾妞嶄綅鐐瑰彂鐢熺殑EMT閫嗗悜榪囩▼闂磋川-涓婄毊杞寲浼氫績榪涘艦鎴愯偪鐦よ漿縐誨悗鐨勭梾鐏?sup style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 12px;">[22]銆?/p> 2.2.2 TGF-尾淇冭繘鑲跨槫琛�綆＄敓鎴?/span> 鑲跨槫鐨勫彂灞曞拰杞Щ闇�瑕佺粡琛�綆′粠瀹夸富鎽勫彇澶ч噺鐨勫吇鍒嗐�傝偪鐦よ綆＄殑鐢熸垚鏄寚鍦ㄥ師鏉ュ凡瀛樺湪鐨勮綆′腑褰㈡垚瀵嗛泦鐨勬柊琛�綆°�傝偪鐦ゅ井鐜涓殑TGF-尾鑳戒綔鐢ㄤ簬鑲跨槫緇嗚優(yōu)錛屼嬌涔嬪垎娉岃綆″唴鐨敓闀垮洜瀛愶紙vascular endothelial growth factor錛孷EGF錛夛紝浠庤�屽埡嬋�鍐呯毊緇嗚優(yōu)鍜屾瘺緇嗚綆¤厰鐢熸垚錛屽鏅氭湡鑲跨槫鐨勮綆″艦鎴愯搗鍒板叧閿�т綔鐢?sup style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 12px;">[23]銆?/sup>鏉庢鑻辯瓑[24]鍦ㄤ復搴婄爺絀朵腑鍙戠幇澧炵敓鏈熷瓙瀹唴鑶滆偪鐦ゆ?zhèn)ｈ�呰娓呬腑VEGF銆乀GF-尾1鐨勮〃杈鵑噺鍧囬珮浜庡仴搴峰鐓х粍濂蟲�э紝涓旀伓鎬ц偪鐦ょ粍楂樹簬鑹�ц偪鐦ょ粍錛屽悓鏃禩GF-尾1琛ㄨ揪閲忎笌VEGF鍛堢幇姝ｇ浉鍏熾�傚垬绔炵瓑[25]鍦ㄤ漢鑶�鑳辯檶緇嗚優(yōu)涓瀯寤哄茍杞煋TGF-尾1灝忓共鎵癛NA琛ㄨ揪杞戒綋錛屽彂鐜癡EGF琛ㄨ揪閲忎笅璋冿紱鑰屽湪楂樿〃杈綯GF-尾1鐨勭檶緇嗚優(yōu)緋諱腑VEGF琛ㄨ揪閲忛殢涔嬪崌楂樸�傝繖浜涜瘉鎹鏄庡湪鑲跨槫寰幆澧冧腑TGF-尾1鍙兘閫氳繃涓婅皟VEGF鐨勮〃杈炬潵淇冭繘鑲跨槫鏂拌綆＄殑鐢熸垚錛岃繘鑰屼績榪涜偪鐦ゅ彂鐢熻縼縐匯�傚彟澶栵紝TGF-尾鑳戒績榪涘熀璐ㄩ噾灞炶泲鐧介叾錛坢atrix metalloproteinase錛孧MP錛夌殑琛ㄨ揪錛岃�孧MP鑳藉鍒嗚В緇嗚優(yōu)澶栧熀璐紝闄嶄綆緇嗚優(yōu)榛忛檮鎬э紝澧炲己琛�綆″唴鐨粏鑳?yōu)鐨剺q佺Щ鑳藉姏錛屼粠鑰屽埄浜庢柊琛�綆＄敓鎴?sup style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 12px;">[26]銆?/p> 2.2.3 TGF-尾璇卞鑲跨槫緇嗚優(yōu)鍏嶇柅閫冮�?nbsp; 鍦ㄨ偪鐦ゅ彂鐢熻繃紼嬩腑錛岃偪鐦ゅ井鐜涓殑TGF-尾鍙互浣胯偪鐦ょ粏鑳?yōu)閫冮伩鏈轟綋鍏嶇柅緋葷粺鐨勭洃瑙嗐�傝嚜鐒舵潃浼わ紙natural killer錛孨K錛夌粏鑳?yōu)閫氳繃鍏剁嫭鐗圭殑鑳藉姏瀵硅偪鐦ょ粏鑳?yōu)鍋氬嚭鍙嶅簲锛屽湪娌℃湁閫傚簲鎬у簲絳旂殑鎯呭喌涓嬭瘑鍒簲嬋�緇嗚優(yōu)錛屼粠鑰屽疄鐜板揩閫熷厤鐤簲絳斻�俆GF-尾鑳芥姂鍒禢K緇嗚優(yōu)涓殑IFN-緯鍜孴-bet琛ㄨ揪錛屼粠鑰屾姂鍒禩h1搴旂瓟[23]銆傛澶栵紝鏍戠獊鐘剁粏鑳?yōu)锛坉endritic cell錛孌C錛夋槸鏈�鏈夋晥鐨凙PC錛屽湪鑲跨槫鍏嶇柅涓搗鐫�鍏抽敭浣滅敤銆俆GF-尾閫氳繃鎶戝埗MHC-鈪?/em>鍩哄洜鐨勮〃杈懼湪浣撳鎶戝埗DC鐨勬姉鍘熷憟閫掕兘鍔涖�侱C鐨勮�愬彈鐢盩GF-尾淇″彿璇卞鍏嶇柅鎶戝埗鍒嗗瓙鍚插摎鑳?錛?-鍙屽姞姘ч叾錛坕ndoleamine 2錛?-dioxygenase錛孖DO錛夊拰綺炬皚閰擱叾浠嬪錛屽湪涔寵吅鐧屽拰榛戣壊绱犵槫鐨勬ā鍨嬩腑TGF-尾閫氳繃涓婅皟嫻嗙粏鑳?yōu)绫籇C涓殑IDO鍜岄楂揇C涓殑CCL22瓚嬪寲鍥犲瓙鏉ヤ粙瀵煎厤鐤�冮�?sup style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 12px;">[27]銆備笌姝ゅ悓鏃訛紝鑲跨槫寰幆澧冧腑鐨凾GF-尾鑳戒績榪汿緇嗚優(yōu)鍚戣皟鑺傛�緇嗚優(yōu)鏂瑰悜鍒嗗寲錛岃繘鑰屾姂鍒禖D8+ T緇嗚優(yōu)浠嬪鐨勫鑲跨槫緇嗚優(yōu)鐨勬潃浼や綔鐢紝璇卞鑲跨槫鍙戠敓鍏嶇柅閫冮�?sup style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 12px;">[28]銆傛澶栵紝鑲跨槫寰幆澧冧腑鐨凾GF-尾鑳戒績榪涘法鍣粏鑳?yōu)浠庡呬h湁鎶楄偪鐦や綔鐢ㄧ殑M1琛ㄥ瀷鍚戞姉鐐庛�佸厤鐤姂鍒剁殑M2琛ㄥ瀷杞彉[11]銆?/p> 3 闈跺悜TGF-尾鐨勫湪鐮旇嵂鐗?/strong> 閴翠簬TGF-尾淇″彿閫氳礬鍦ㄨ偪鐦ょ殑鍙戠敓銆佸彂灞曞拰杞Щ榪囩▼涓彂鎸ョ潃宸ㄥぇ鐨勪綔鐢紝閫氳繃鎶戝埗TGF-尾鐨勪駭鐢熸垨鑰呴樆鏂叾淇″彿杞絳夐�斿緞浠ラ檺鍒惰偪鐦よ繘灞曞凡鎴愪負鎶楄偪鐦ゆ不鐤楃殑涓�縐嶆湁鏁堟墜孌點�傜洰鍓嶏紝涓村簥涓婂凡鏈夊縐嶉澏鍚慣GF-尾鐨勫湪鐮旇嵂鐗╋紝涓昏鍖呭惈鍗曞厠闅嗘姉浣擄紙鍗曟姉錛夊拰TGF-尾R铻嶅悎铔嬬櫧銆侀澏鍚慣GF-尾鐨勫弽涔夊鏍歌嫹閰擱摼鍙奣GF-尾R嬋�閰舵姂鍒跺墏銆?/p> 3.1 鍗曟姉鍜岃瀺鍚堣泲鐧?/strong> Fresolimumab錛圙C1008錛夋槸涓�縐嶄漢婧愭�?IgG4鎶桾GF-尾鍗曟姉錛岀敱1D11榧犳簮鎶椾綋緇忓祵鍚堟敼閫犺幏寰楋紝鍙悓鏃墮澏鍚慣GF-尾1銆?銆?錛岀洰鍓嶅湪鏅氭湡鎭舵�ч粦鑹茬礌鐦ゅ拰鑲劇粏鑳?yōu)鐧屾?zhèn)ｈ�呬腑榪涜鈪犳湡涓村簥璇曢獙銆傛?zhèn)ｈ�呭湪絎?銆?8銆?2鍜?6澶╂帴鍙楅潤鑴夋敞灝凢resolimumab錛屽墏閲忛�掑銆傝嚦灝戣揪鍒扮柧鐥呯ǔ瀹氱殑鎮(zhèn)ｈ�呭彲鎺ュ彈寤墮暱娌葷枟錛屽寘鎷瘡2鍛?鍓傛敞灝勶紝鏈�澶?涓澶栫殑鐤楃▼銆傛湁29渚嬫?zhèn)ｈ�呮帴鍙椾簡娌葷枟錛屽叾涓?2渚嬪湪鍓傞噺閫掑涓紝7渚嬪湪瀹夊叏闃熷垪鎵╁睍涓�傛病鏈夎瀵熷埌鍓傞噺闄愬埗鎬ф瘨鎬э紝騫朵笖紜畾鏈�澶у墏閲?5 mg/kg鏄畨鍏ㄧ殑銆傚叾涓彲閫嗘�х毊鑲よ鑶滄鐨槫/槌炵姸緇嗚優(yōu)鐧岋紙4渚嬫?zhèn)ｈ�咃級鍜岃鍖栬繃搴︾殑鍙戝睍鏄瀵熷埌鐨勪富瑕佷笉鑹簨浠躲�?渚嬫伓鎬ч粦鑹茬礌鐦ゆ?zhèn)ｈ�呰幏寰楅儴鍒嗙紦瑙ｏ紝6渚嬬梾鎯呯ǔ瀹氾紝涓綅鏃犺繘灞曠敓瀛樻湡涓?4鍛?sup style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 12px;">[29]銆?/p> SAR439459鏄硶鍥借禌璇鴻彶鍏徃鍦ㄧ爺鐨勪竴縐嶉澏鍚慣GF-尾鐨勫崟鎶楋紝SAR439459鍗曡嵂鎴栬仈鍚堟姉紼嬪簭鎬ф浜¤泲鐧?鑽墿瑗跨背鏅埄鍗曟姉娌葷枟榪涘睍鏈熷疄浣撶槫瀹夊叏鎬у強鎶楄偪鐦ゆ椿鎬х殑涓村簥璇曢獙姝ｅ湪鎷涘嫙鎮(zhèn)ｈ�?NCT03192345)銆?/p> LY3022859鏄竴縐嶆姉TGF-尾R鈪″崟鎶楋紝鍦ㄤ復搴婂墠璇勪及涓涔寵吅鐧屾湁鐤楁晥錛屼絾鈪犳湡涓村簥璇曢獙鍦?4渚嬭漿縐繪�ц偪鐦ゆ?zhèn)ｈ�呬腑瑙傚療鍒頒笉鍙帶鐨勭粏鑳?yōu)鍥犲瓙閲婃攧』煎悎寰佸Q屼嬌璇曢獙鎻愬墠緇堟[30]銆?/p> SRK-181鏄竴縐岻gG4/kappa浜氬瀷鐨勫叏浜烘簮鎶椾綋錛岃兘楂樼壒寮傛�с�侀珮浜插拰鍔涘湴緇撳悎TGF-尾1鍓嶄綋澶嶅悎鐗╋紝浣嗕笉緇撳悎TGF-尾2鎴朤GF-尾3銆傚湪涓村簥鍓嶇爺絀朵腑錛屼嬌鐢⊿RK-181鑱斿悎鎶桺D-1鍗曟姉娌葷枟灝忛紶鑲跨槫妯″瀷鑳藉璁╂晥搴擳緇嗚優(yōu)鍦ㄨ偪鐦ゅ井鐜涓蹈娑﹀茍鎵╁錛岃瀵熷埌鎸佺畫鐨勬姉鑲跨槫鏁堝簲[31]銆傚悓鏃剁敱浜庨珮鐗瑰紓鎬э紝SRK-181鍦ㄦ垚騫村ぇ榧犱腑鐨勬渶澶у墏閲忓鍔犲埌姣忓懆緇欒嵂100 mg/kg涔熸病鏈夎瀵熷埌鑽墿姣掓�с�?/p> AVID200鏄竴綾婚珮浜插拰鍔汿GF-尾R鈪?Fc铻嶅悎铔嬬櫧鑽墿錛屽彲鍦╬mol綰ф按騫蟲湁鏁堜腑鍜孴GF-尾1鍜孴GF-尾3錛屼絾涓嶇粨鍚圱GF-尾2銆侫VID200鐨勯�夋嫨闈跺悜鎬т嬌鍏舵垚涓虹氦緇村寲鐤劇梾鍜岃偪鐦ゅ厤鐤不鐤椾腑鏋佸叿寮�鍙戞綔鍔涚殑鑽墿銆傜洰鍓嶈鑽凡榪涘叆鈪犳湡涓村簥鐮旂┒[32]銆?/p> M7824鏄痙鍥介粯鍏嬪叕鍙哥爺鍙戠殑涓�縐嶅弻鍔熻兘铻嶅悎铔嬬櫧錛岃兘鐗瑰紓鎬у湴鍚屾椂緇撳悎紼嬪簭鎬ф浜″彈浣撻厤浣?錛坧rogrammed death-ligand 1錛孭D-L1錛夊拰 TGF-尾銆傚湪灝忛紶鑲跨槫妯″瀷涓紝M7824姣旂敤鎶桺D-L1鎶椾綋鎴朤GF-尾闄烽槺娌葷枟鑳芥洿鏈夋晥鍦版姂鍒惰偪鐦ょ敓闀垮拰杞Щ[33]銆備嬌鐢∕7824娌葷枟鏅氭湡闈炲皬緇嗚優(yōu)鑲虹檶錛屾?zhèn)ｈ�呬腑浣嶆�葷敓瀛樻湡涓?7.1涓湀錛屼笌鎶桺D-1鍗曟姉娌葷枟鐩告瘮鏈夋樉钁楀歡闀褲�傚彟澶栵紝闀胯揪3騫寸殑闅忚緇撴灉琛ㄦ槑M7824瀵筆D-L1楂樿〃杈劇殑鎮(zhèn)ｈ�呭叿鏈夊彲鎺х殑瀹夊叏鎬э紝涓斿叿鏈夎緝闀跨殑緙撹В鎸佺畫鏃墮棿鍜岃緝濂界殑闀挎湡涓村簥鑾風泭[11]銆備絾鍦ㄦ不鐤楁帴鍙楄繃鍏嶇柅媯�鏌ョ偣鎶戝埗鍓傚悗鐤劇梾榪涘睍鐨勫井鍗槦楂樺害涓嶇ǔ瀹?閿欓厤淇緙洪櫡瀹炰綋鐦ゆ?zhèn)ｈ�呯殑鈪℃湡涓村簥鐮旂┒錛圢CT03436563錛変腑錛孧7824鏈樉紺哄嚭鎶楄偪鐦ゆ椿鎬ц�屼互澶辮觸鍛婄粓錛屽寘鍚?59渚嬫?zhèn)ｈ�呯殑M7824鍗曡嵂浜岀嚎娌葷枟灞�閮ㄦ櫄鏈熸垨杞Щ鎬ц儐閬撶檶鐨勨叀鏈熶復搴婅瘯楠屼篃鍥犳湭杈懼埌涓昏緇堢偣鑰岀粓姝€�傜洰鍓嶏紝M7824榪樻湁瀹鐧屻�佷鉤鑵虹檶銆佸翱璺笂鐨檶銆侀潪灝忕粏鑳?yōu)鑲虹檶鑱斿悎鐤楁硶绛夊椤瑰浜庝笉鍚岄樁娈电殑鋸湾簥璇曢獙銆?/p> 3.2 闈跺悜TGF-尾鐨勫弽涔夊鏍歌嫹閰擱摼 鍙嶄箟瀵℃牳鑻烽吀閾続P12009闈跺悜娌夐粯TGF-尾2 mRNA錛岀敤浜庢伓鎬ч粦鑹茬礌鐦ゅ拰鑳惰川鐦ょ殑娌葷枟銆傚湪闅炬不鍨嬭兌璐ㄧ槫鐨勨厾/鈪℃湡涓村簥璇曢獙涓紝10 渭mol/L AP12009娌葷枟緇勭殑涓綅鐢熷瓨鏈熶負12.0涓湀錛?0 渭mol/L AP12009娌葷枟緇勪負13.1涓湀錛屾爣鍑嗗寲娌葷枟緇勪負11.0涓湀錛岃〃鏄嶢P12009鍙兘鏄竴縐嶅緢鏈夊笇鏈涚殑鎶楄偪鐦よ嵂鐗?sup style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 12px;">[34]錛屽叿鏈夎緝楂樼殑寮�鍙戞綔鍔涖�傜洰鍓嶏紝AP12009宸茶繘鍏ユ不鐤楄漿縐繪�ч粦鑹茬礌鐦ゃ�佽儼鑵虹檶鍜岃漿縐繪�х粨鐩磋偁鐧岀殑鈪㈡湡涓村簥鐮旂┒銆?/p> STP705鏄竴縐嶅湪鐮旂殑闈跺悜TGF-尾1鍜?em style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">COX-2鍩哄洜鐨勫皬騫叉壈RNA娌葷枟鑽墿錛岀敱澶氳偨綰崇背棰楃矑閰嶅埗鑰屾垚銆傚湪涓村簥鍓嶅姩鐗╂ā鍨嬩腑錛孲TP705緇欒嵂澧炲姞浜員緇嗚優(yōu)瀵硅倽鑴忚偪鐦ょ殑娓楅�忥紝騫跺鍔犱簡鑲濈粏鑳?yōu)鐧屾ā鍨嬩腑鎶桺D-L1鎶椾綋鐨勭枟鏁堛�傚湪1欏規(guī)鍦ㄨ繘琛岀殑璇勪及STP705鐨勨叀鏈熶復搴婄爺絀朵腑錛岄�氳繃姣忓懆1嬈＄梾鐏跺唴娉ㄥ皠錛屽叡鎸佺畫6鍛ㄧ敤浜庢不鐤楅潪榛戣壊绱犵槫鐨偆鐧岋紝涓湡鍒嗘瀽琛ㄦ槑涓�浜涙?zhèn)ｈ�呯殑鐥呭彉鍑虹幇緇勭粐瀛︽竻闄わ紝涓旀帴鍙楁不鐤楃殑鎮(zhèn)ｈ�呮病鏈夊嚭鐜扮毊鑲や笉鑹弽搴?sup style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 12px;">[35]銆?/p> 3.3 TGF-尾R嬋�閰舵姂鍒跺墏 灝忓垎瀛愭姂鍒跺墏SB-431542鑳界壒寮傛�х粨鍚堝埌TGF-尾R鈪狅紝閫氳繃鎶戝埗鍏舵縺閰舵椿鎬ф潵闃繪柇涓嬫父Smad2/3紓烽吀鍖栵紝浠庤�岄樆鏂璗GF-尾/Smad淇″彿閫氳礬銆係B-431542鍦ㄦ伓鎬х緇忚兌璐ㄧ槫緇嗚優(yōu)涓兘澶熸姂鍒惰綆＄敓鎴愶紝闃繪柇鑲跨槫緇嗚優(yōu)鐨勮縼縐諱綔鐢紝鍚屾椂鑳芥湁鏁堟姂鍒禩GF-尾璇卞鐨勪漢楠ㄨ倝鐦ょ粏鑳?yōu)澧瀸D栧拰榪佺Щ[36]銆?/sub> Galunisertib錛圠Y2157299錛夋槸鐩墠鐮旂┒鏈�騫挎硾鐨勬柊鍨嬪彛鏈嶅皬鍒嗗瓙鎶戝埗鍓傦紝鍏朵綔鐢ㄦ満鍒朵笌SB-431542鐩稿悓錛岃兘鎶戝埗TGF-尾R鈪犳縺閰舵椿鎬?sup style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 12px;">[37]銆侴alunisertib鍦ㄤ鉤鑵虹檶銆佺粨鑲犵檶銆佽偤鐧屽拰鑲濈檶寮傜縐繪鑲跨槫涓叿鏈夋姉鑲跨槫媧繪�?sup style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 12px;">[38]銆傚湪浜轟綋鍓傞噺鐮旂┒涓紝56渚嬭兌璐ㄧ槫鎮(zhèn)ｈ�呬腑鏈?2渚嬭瀵熷埌涓村簥鑾風泭錛屼笖300 mg/d鐨凣alunisertib瀹夊叏鎬ц壇濂斤紝鍙敤浜庢湭鏉ョ殑涓村簥鐮旂┒[39]銆?/p> Vactosertib錛圱EW-7197錛夋槸澶勪簬涓村簥寮�鍙戜腑鐨凾GF-尾R鈪犻�夋嫨鎬у皬鍒嗗瓙鎶戝埗鍓傦紝鐗瑰紓鎬ч澏鍚慣GF-尾R鈪犵殑鑵鴻嫹-5鈥?涓夌７閰哥粨鍚堜綅鐐癸紝浠庤�屾姂鍒禨mad2鍜孲mad3鐨勭７閰稿寲鏉ラ樆鏂笅娓鎬俊鍙烽�氳礬銆傗厾鏈熷墏閲忛�掑鐮旂┒鍦ㄦ櫄鏈熷疄浣撶槫鎮(zhèn)ｈ�呬腑璇勪及浜哣actosertib鐨勫畨鍏ㄦ�с�佹湁鏁堟�т互鍙婁笌TGF-尾鍙嶅簲鐗瑰緛鐨勭浉鍏蟲�э紝鎮(zhèn)ｈ�呭湪鍓傞噺鑼冨洿鍐咃紙30~340 mg錛夋瘡鏃?嬈℃帴鍙梀actosertib錛屾寔緇? d錛屼紤鎭? d銆傜粨鏋滆〃鏄嶸actosertib鐨勫畨鍏ㄦ�у拰鑰愬彈鎬ц壇濂斤紝浣嗘渶澶ц�愬彈鍓傞噺灝氭湭紜畾錛涙帴鍙椻墺140 mg娌葷枟鐨?7渚嬫?zhèn)ｈ�呬腑鏈?渚嬬梾鎯呯ǔ瀹氾紙35.3%錛夛紝騫朵笖鎴愮氦緇寸粏鑳?yōu)TGF-尾鍙嶅簲鐗瑰緛姣旇繘琛屾�х柧鐥呮?zhèn)ｈ�呮洿楂?sup style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 12px;">[40]銆?/p> 4 灞曟湜 TGF-尾鏄竴縐嶅鏁堢粏鑳?yōu)鍥犲瓙锛屾犚?guī)嵁鎵�澶勭殑鑲跨槫寰幆澧冿紝鍙互浜х敓淇冭偪鐦ゆ垨鎶楄偪鐦や綔鐢ㄣ�傚湪鑲跨槫褰㈡垚鍚庯紝TGF-尾鑳介�氳繃浠嬪EMT銆佷績榪涜綆＄敓鎴愩�佽瀵煎厤鐤�冮�哥瓑浣滅敤鏉ヤ績榪涜偪鐦ょ粏鑳?yōu)鐨勭敓闀裤�佹蹈娑︿笌杞Щ銆傚敖綆″ぇ閲忎復搴婂墠鍜岃漿鍖栫爺絀惰〃鏄庯紝闃繪柇TGF-尾鏄竴縐嶆綔鍦ㄦ湁鏁堢殑娌葷枟絳栫暐錛屼絾浠庡疄楠屽鍒頒復搴婄殑杞寲榪涘睍緙撴參錛岀洰鍓嶅皻鏈湁闈跺悜TGF-尾鑽墿琚壒鍑嗙敤浜庣檶鐥囨不鐤楋紝榪欏彲鑳戒笌TGF-尾鐨勫弻閲嶄綔鐢ㄦ湁鍏熾�傞樆鏂璗GF-尾淇″彿閫氳礬錛屽悓鏃惰В闄よ偪鐦ゅ井鐜鐨勫厤鐤姂鍒訛紝宸叉垚涓虹洰鍓嶇爺絀墮澏鍚慣GF-尾鑽墿鐨勭儹闂ㄦ柟鍚戯紝鑰屽浣曡璁GF-尾鎶戝埗鍓備笌鍏嶇柅媯�鏌ョ偣鎶戝埗鍓傜殑鑱旂敤榪橀渶瑕佽繘涓�姝ユ�濊�冧笌鎺㈢儲銆?/p> 寮曠敤鏈枃錛氶┈閽? 杞寲鐢熼暱鍥犲瓙尾鍦ㄨ偪鐦ゅ井鐜涓殑浣滅敤鍙婂叾闈跺悜鑽墿鐮旂┒榪涘睍 [J]. 鍥介檯鐢熺墿鍒跺搧瀛︽潅蹇? 2023, 46(2): 103-108. DOI: 10.3760/cma.j.cn311962-20220127-00009
